About Endometrial & Uterine Cancer

High exposure to estrogens (either in women who produce extra estrogen or if given as a drug) is a key risk factor for the development of endometrial tumors. Because estrogen is produced in fat cells, obese women, women treated with postmenopausal estrogens or women with estrogen-producing tumors are at higher risk for endometrial cancer. Tumors in the uterus mostly arise in the glandular lining and are endometrial adenocarcinomas (endometrial cancer). Benign (leiomyomas) and malignant tumors (leiomyosarcomas) can occur in the uterine smooth muscle and have very different clinical features. One common symptom is vaginal bleeding, which typically spurs a visit to a primary care provider or gynecologist. Diagnosis is typically by endometrial biopsy.

Hyperthermia is a non-invasive, FDA approved treatment covered by most insurance.

Welcome to Hyperthermia Cancer Institute - Video Preview

Welcome to Hyperthermia Cancer Institute

What Exactly is Hyperthermia

What Exactly Is Hyperthermia?

Hyperthermia is Effective at Treating Most Endometrial & Uterine & Melanoma Cancers

Melanoma

Hyperthermia increases the likelihood of a complete response in melanoma cancers by upwards of 50% when combined with radiation therapy.

Radiation Therapy Alone
Radiation Therapy + Hyperthermia
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Melanoma Treatment Statistics

Breast Vernon CC et al. and van der Zee et al., Int. J. Radiation Oncology Biol. Phys. 1996; 35(4) 731-744 Head & Neck Valdagni et al., Int. J. Radiation Oncology Biol. Phys. 1994; 28: 163-169
Melanoma Overgaard J et al., Int. J. Hyperthermia 1996; 12(1): 3-20 Cervical van der Zee et al. Int. J. Hyperthermia 2002; 18(1): 1-12, Berdov, BA and Menteshashvili, GZ.
Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Int. J. Hyperthermia 1990; 6(5): 881-890

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We Treat All Stages and Types of Endometrial & Uterine Cancer

  • Endometrial Carcinoma (most common)
  • Leiomyosarcomas of the Uterus
  • What We Do
  • Target the tumor
  • Do not put fragile healthy tissues including heart, lungs, lymph nodes and any other affected organ at risk
  • Improve the effectiveness of radiation and/or systemic therapy

How Hyperthermia Therapy Works

Research has demonstrated that hyperthermia, when combined with chemotherapy, radiation therapy and immunotherapy, improves outcomes in patients with endometrial or uterine cancer. The application of hyperthermia to a tumor can have numerous positive effects on cancer cells. In simplest terms, heat from hyperthermia therapy disrupts cell membranes and increases blood flow to the tumor, making the tumor more sensitive and vulnerable both to your body’s natural immune defenses and to other cancer therapies.

Hyperthermia Improves Outcomes

in Patients with Endometrial or Uterine Cancer

Research has demonstrated that hyperthermia, when combined with chemotherapy, radiation therapy and immunotherapy, improves outcomes in patients with endometrial cancer.

Hyperthermia can be added at any time to one’s endometrial cancer treatment in Irvine. Optimally, hyperthermia treatment is initiated as soon as the patient begins receiving radiation therapy or chemotherapy. Improving your therapeutic regimen leads to the best outcome.

For all patients, the goal is to choose the right therapy or combination of therapies that lead to the best outcome while minimizing side effects. Hyperthermia often has no or minimal side effects and has no known adverse effects on normal tissue. Adding hyperthermia can maximize the effectiveness of your therapeutic regimen without risking sensitive surrounding organs.

Hyperthermia does the following:

  • Increases blood flow to tumors creating a high-oxygen environment, which makes radiation therapy work better
  • Allows for chemotherapy to penetrate deep into the center of the tumor where it otherwise has difficulty reaching
  • Can stimulate an immune response reaction within the tumor improving your body’s ability to fight cancer

Patient Reviews

“My mom received hyperthermia here in conjunction with five rounds of chemotherapy for her stage four lung cancer. She saw a reduction in tumor burden by over 50% and her cancer stabilized.The team at HCI is thoughtful and caring – I recommend hyperthermia for all cancer patients undergoing chemo or radiation.”

“I went to Hyperthermia cancer institute 5-6 days a week for 4 weeks. On my birthday, I received a call from my oncologist and they could not find a trace of tumor in the MRI. The tumor went to a zero! It is a complete success. I am so happy to have come to HCI.”

“I just wanted to let you know that I am in my first cancer-free year! Thank you again for the time, effort and care given to me during my time of need. I will continue to spread the word of incredible hyperthermia treatments to those in need.”

– Merry Chase

“The hyperthermia treatments were the major difference in treating my cancer. I am forever grateful for this technology.”

– Carla Olson

FAQ

Hyperthermia treatment is non-invasive and non-toxic. There is no damage to normal healthy tissues during your session, meaning it can maximize the efficacy of other treatments like radiation and chemo without risking damage to vital organs. Most patients find it easy to tolerate and do not experience side effects.

Hyperthermia increases blood flow to tumors, making them more susceptible to chemotherapy. It also helps chemotherapy to better penetrate the tumor’s core, something that is difficult for chemo to achieve on its own. Lastly, after chemotherapy has damaged the cancer cells’ DNA, hyperthermia prevents the body from repairing the DNA, maintaining the cells’ vulnerability to chemo.
Radiation is most effective in an oxygen-rich atmosphere. With hyperthermia, more oxygen enters the tumor’s core through increased blood flow, allowing for more dramatic radiation treatment outcomes. When radiation damages the DNA in cancer cells, hyperthermia prevents the body from repairing the cells’ DNA, keeping the cancer cells vulnerable and susceptible to radiation.
Hyperthermia therapy is generally well-tolerated, with most patients experiencing minimal to no discomfort during the session. The treatment is designed to be gentle, and any mild sensations of warmth are temporary and subside quickly after the session.
A typical hyperthermia session lasts between 30 minutes and an hour, depending on the treatment area and the patient’s specific needs. Your care team will provide a detailed schedule tailored to your therapy plan.

While hyperthermia is most commonly paired with radiation or chemotherapy, it can also enhance outcomes when used in conjunction with surgery, especially for addressing residual cancer cells post-surgery. Your doctor will advise if this combination is suitable for your case.

No, hyperthermia therapy is a non-invasive outpatient procedure. Patients can return home shortly after each session and continue with their regular activities, making it a convenient addition to their cancer treatment plan.
Most patients feel little to no side effects after a hyperthermia session. Some may experience mild warmth or redness in the treated area, which typically resolves quickly. Your care team will provide aftercare instructions to ensure a comfortable recovery and maximize the benefits of your treatment.

NOTE:

The studies cited above include traditional hyperthermia treatments which are applied near the surface of the body. However, they also include data from studies using Hyperthermic Intraperitoneal Chemotherapy (HIPEC). HIPEC is a procedure where heated chemotherapy is infused directly into the abdominal cavity at the time of surgery for endometrial cancer. This one-time heating has been demonstrated to improve outcomes. The hyperthermia treatment used at HCI is non-invasive and externally applied using ultrasound technology, delivered over several treatments.

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