Over 60,000 new uterine cancers are diagnosed each year in the U.S.
Over 60,000 new uterine cancers are diagnosed each year in the U.S.

High exposure to estrogens (either in women who produce extra estrogen or if given as a drug) is a key risk factor for the development of endometrial tumors. Because estrogen is produced in fat cells, obese women, women treated with postmenopausal estrogens or women with estrogen-producing tumors are at higher risk for endometrial cancer. Tumors in the uterus mostly arise in the glandular lining and are endometrial adenocarcinomas (endometrial cancer). Benign (leiomyomas) and malignant tumors (leiomyosarcomas) can occur in the uterine smooth muscle and have very different clinical features. One common symptom is vaginal bleeding, which typically spurs a visit to a primary care provider or gynecologist. Diagnosis is typically by endometrial biopsy.
Hyperthermia increases the likelihood of a complete response in melanoma cancers by upwards of 50% when combined with radiation therapy.
Breast Vernon CC et al. and van der Zee et al., Int. J. Radiation Oncology Biol. Phys. 1996; 35(4) 731-744 Head & Neck Valdagni et al., Int. J. Radiation Oncology Biol. Phys. 1994; 28: 163-169
Melanoma Overgaard J et al., Int. J. Hyperthermia 1996; 12(1): 3-20 Cervical van der Zee et al. Int. J. Hyperthermia 2002; 18(1): 1-12, Berdov, BA and Menteshashvili, GZ.
Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. Int. J. Hyperthermia 1990; 6(5): 881-890
Research has demonstrated that hyperthermia, when combined with chemotherapy, radiation therapy and immunotherapy, improves outcomes in patients with endometrial or uterine cancer. The application of hyperthermia to a tumor can have numerous positive effects on cancer cells. In simplest terms, heat from hyperthermia therapy disrupts cell membranes and increases blood flow to the tumor, making the tumor more sensitive and vulnerable both to your body’s natural immune defenses and to other cancer therapies.
in Patients with Endometrial or Uterine Cancer
Research has demonstrated that hyperthermia, when combined with chemotherapy, radiation therapy and immunotherapy, improves outcomes in patients with endometrial cancer.
Hyperthermia can be added at any time to one’s endometrial cancer treatment in Irvine. Optimally, hyperthermia treatment is initiated as soon as the patient begins receiving radiation therapy or chemotherapy. Improving your therapeutic regimen leads to the best outcome.
For all patients, the goal is to choose the right therapy or combination of therapies that lead to the best outcome while minimizing side effects. Hyperthermia often has no or minimal side effects and has no known adverse effects on normal tissue. Adding hyperthermia can maximize the effectiveness of your therapeutic regimen without risking sensitive surrounding organs.
“My mom received hyperthermia here in conjunction with five rounds of chemotherapy for her stage four lung cancer. She saw a reduction in tumor burden by over 50% and her cancer stabilized.The team at HCI is thoughtful and caring – I recommend hyperthermia for all cancer patients undergoing chemo or radiation.”
“I just wanted to let you know that I am in my first cancer-free year! Thank you again for the time, effort and care given to me during my time of need. I will continue to spread the word of incredible hyperthermia treatments to those in need.”
– Merry Chase
“The hyperthermia treatments were the major difference in treating my cancer. I am forever grateful for this technology.”
– Carla Olson
The team at HCI is outstanding. They treated us with so much care and respect! The technology helped my wife tremendously and the treatment is relatively comfortable compared to many cancer therapies. We highly recommend. Oh, and it is in one of the most beautiful places on the planet!
I went to Hyperthermia cancer institute 5-6 days a week for 4 weeks. On my birthday, I received a call from my oncologist and they could not find a trace of tumor in the MRI. The tumor went to a zero! It is a complete success.
Dr. Pinzone and the whole team are fantastic and truly care about their patients. I highly recommend!
My mom received hyperthermia here in conjunction with five rounds of chemotherapy for her stage four lung cancer. She saw a reduction in tumor burden by over 50% and her cancer stabilized. I recommend hyperthermia for all cancer patients undergoing chemo or radiation.
The team at HCI is outstanding. They treated us with so much care and respect! The technology helped my wife tremendously and the treatment is relatively comfortable compared to many cancer therapies. We highly recommend. Oh, and it is in one of the most beautiful places on the planet!
I went to Hyperthermia cancer institute 5-6 days a week for 4 weeks. On my birthday, I received a call from my oncologist and they could not find a trace of tumor in the MRI. The tumor went to a zero! It is a complete success.
Dr. Pinzone and the whole team are fantastic and truly care about their patients. I highly recommend!
Hyperthermia treatment is non-invasive and non-toxic. There is no damage to normal healthy tissues during your session, meaning it can maximize the efficacy of other treatments like radiation and chemo without risking damage to vital organs. Most patients find it easy to tolerate and do not experience side effects.
While hyperthermia is most commonly paired with radiation or chemotherapy, it can also enhance outcomes when used in conjunction with surgery, especially for addressing residual cancer cells post-surgery. Your doctor will advise if this combination is suitable for your case.
Our cancer center in Irvine understands that It can be overwhelming to research cancer treatments. We’ve selected a few studies from trusted sources to help you understand the benefits of hyperthermia therapy in treatment for Endometrial or Uterine Cancers.
The studies cited above include traditional hyperthermia treatments which are applied near the surface of the body. However, they also include data from studies using Hyperthermic Intraperitoneal Chemotherapy (HIPEC). HIPEC is a procedure where heated chemotherapy is infused directly into the abdominal cavity at the time of surgery for endometrial cancer. This one-time heating has been demonstrated to improve outcomes. The hyperthermia treatment used at HCI is non-invasive and externally applied using ultrasound technology, delivered over several treatments.