By increasing the blood flow to a tumor, hyperthermia delivers more chemotherapy to all parts of the tumor, especially to the tumor’s core where it is difficult for chemotherapy to reach. Hyperthermia also makes the outer membrane of tumor cells more porous, which allows chemotherapy and other medications to better penetrate the tumor cells, further amplifying the effects of chemotherapy. Finally, many types of chemotherapy damage the DNA of cancer cells, targeting them for destruction. Hyperthermia works by preventing your body from repairing the cancer cell DNA, thereby keeping the cancer cell vulnerable to chemotherapy.
Radiation therapy is more effective in a high-oxygen environment. Because hyperthermia increases the blood flow to a tumor, more oxygen flows to all parts of the tumor, including the tumor’s center. Radiation therapy also damages cancer cell DNA, targeting them for destruction. Hyperthermia prevents your body from repairing the cancer cell DNA, thereby keeping the cancer cell vulnerable to radiation therapy.
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